About Instylan
INSTYLAN is a sterile hyaluronic acid-based solution specifically designed to restore and protect the bladder's mucosal lining. It is instilled directly into the bladder, helping to:
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Repair and reinforce the glycosaminoglycan (GAG) layer, which is often damaged in recurrent urinary tract infections (UTIs) and interstitial cystitis.
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Reduce bladder inflammation and irritation, providing symptomatic relief such as reduced pain, urgency, and frequency.
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Lower recurrence rates of UTIs by creating a protective barrier that limits bacterial adhesion and penetration.
Who is Instylan for?
Patients with chronic inflammatory diseases of the bladder.
Recurrent UTI's, painful bladder syndrome and cystitis.
Patients who receive radiation therapy for the pelvic area.
Patients after cystoscopy, urethroscopy, TUR.
50 ml disposable bag pre-filled with Hyaluronic Acid
Protective connector
The universal nozzle for an urethral catheter
Additional port to add: antiseptics, antibiotics, analgesics, hormones (healthcare professionals discretion)
Dosing Administration
Instylan is intended for irrigation of the bladder cavity when using a urological catheter
Instylan into the bladder can be performed by a doctor with special training, or the patient can conduct self catheterisation in compliance with all aseptical rules
Instylan is administered intravesically, once a week
The treatment course is from 4 up to 12 installations
Before administration of Instalyn the bladder should be emptied
Before use the temperature of the solutions must be at least 20˚C
After installation keep from urinating for at least 30 minutes.
Mechanism of action
When placed into the cavity of the bladder, Instylan creates a viscoelastic film on the surface of the mucous membrane. Due to the specific characteristics of the Hyaluronic Acid, the basic substance creates a a robust GAG layer to replenish the bladder mucous lining, in the interstitial space of the connective tissue.
Indications
Irrigation provides temporary protection and restoration of the mucous membrane of the bladder in case of:
Chronic / recurrent cystitis
Interstitial cystitis
Hyperactive bladder
Recurrent UTIs
Radiation cystitis
INSTYLAN (hyaluronic acid)
The molecular weight of a bladder instillation determines it's ability to hold onto water molecules.
INSTYLAN currently possesses the highest molecular weight of any comparable product available on the UK market.
